How does a noncompetitive inhibitor decrease the rate of an enzyme reaction?

How does a noncompetitive inhibitor decrease the rate of an enzyme reaction? 





A) by binding at the active site of the enzyme
B) by changing the shape of the enzyme's active site
C) by changing the free energy change of the reaction
D) by acting as a coenzyme for the reaction
E) by decreasing the activation energy of the reaction






Answer: B


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